A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs
Identifieur interne : 00E480 ( Main/Exploration ); précédent : 00E479; suivant : 00E481A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs
Auteurs : N. B. Piller [Australie] ; R. Gwyn Morgan [Australie] ; J. R. Casley-Smith [Australie]Source :
- British Journal of Plastic Surgery [ 0007-1226 ] ; 1988.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Attribution aléatoire, Bras, Complications postopératoires (traitement médicamenteux), Essais cliniques comme sujet, Femelle, Humains, Jambe, Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Mastectomie, Mâle, Méthode en double aveugle, O-(bêta-Hydroxyéthyl)rutosides (administration et posologie), O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés), O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique), Rutoside (analogues et dérivés), Température cutanée ().
- MESH :
- administration et posologie : O-(bêta-Hydroxyéthyl)rutosides.
- analogues et dérivés : O-(bêta-Hydroxyéthyl)rutosides, Rutoside.
- physiopathologie : Lymphoedème.
- traitement médicamenteux : Complications postopératoires, Lymphoedème.
- usage thérapeutique : O-(bêta-Hydroxyéthyl)rutosides.
- Adulte d'âge moyen, Attribution aléatoire, Bras, Essais cliniques comme sujet, Femelle, Humains, Jambe, Mastectomie, Mâle, Méthode en double aveugle, Température cutanée.
English descriptors
- KwdEn :
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Hydroxyethylrutoside (administration & dosage), Hydroxyethylrutoside (analogs & derivatives), Hydroxyethylrutoside (therapeutic use), Leg, Lymphedema (drug therapy), Lymphedema (physiopathology), Male, Mastectomy, Middle Aged, Postoperative Complications (drug therapy), Random Allocation, Rutin (analogs & derivatives), Skin Temperature (drug effects).
- MESH :
- chemical , administration & dosage : Hydroxyethylrutoside.
- chemical , analogs & derivatives : Hydroxyethylrutoside, Rutin.
- chemical , therapeutic use : Hydroxyethylrutoside.
- drug effects : Skin Temperature.
- drug therapy : Lymphedema, Postoperative Complications.
- physiopathology : Lymphedema.
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Leg, Male, Mastectomy, Middle Aged, Random Allocation.
Abstract
Abstract: A randomised, double-blind, cross-over trial was performed on 26 patients with post-mastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took O-(β-hydroxyethyl)-rutosides (oxerutin; “Paroven®”, “Venoruton®”, Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p<0.05 to 0.01) and their circumferences (p<0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p<0.01 to 0.001). There was a lowering of the elevated skin temperatures (p<0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p<0.05 to 0.01), and an increased mobility of their limbs (p<0.0001). Most patients (70%) preferred the active drug (p<0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for the placebo (p<0.0001).
Url:
DOI: 10.1016/0007-1226(88)90139-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 007132
- to stream Istex, to step Curation: 007132
- to stream Istex, to step Checkpoint: 005A41
- to stream Main, to step Merge: 00F170
- to stream PubMed, to step Corpus: 006262
- to stream PubMed, to step Curation: 006262
- to stream PubMed, to step Checkpoint: 006262
- to stream Ncbi, to step Merge: 009669
- to stream Ncbi, to step Curation: 009669
- to stream Ncbi, to step Checkpoint: 009669
- to stream Main, to step Merge: 00F004
- to stream Main, to step Curation: 00E480
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name></author><author><name sortKey="Morgan, R Gwyn" sort="Morgan, R Gwyn" uniqKey="Morgan R" first="R. Gwyn" last="Morgan">R. Gwyn Morgan</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F1AB2C3158F33CBC34B96C103F24B762D9D9564C</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1016/0007-1226(88)90139-7</idno><idno type="url">https://api.istex.fr/document/F1AB2C3158F33CBC34B96C103F24B762D9D9564C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">007132</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">007132</idno><idno type="wicri:Area/Istex/Curation">007132</idno><idno type="wicri:Area/Istex/Checkpoint">005A41</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">005A41</idno><idno type="wicri:doubleKey">0007-1226:1988:Piller N:a:double:blind</idno><idno type="wicri:Area/Main/Merge">00F170</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:3278764</idno><idno type="wicri:Area/PubMed/Corpus">006262</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006262</idno><idno type="wicri:Area/PubMed/Curation">006262</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006262</idno><idno type="wicri:Area/PubMed/Checkpoint">006262</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006262</idno><idno type="wicri:Area/Ncbi/Merge">009669</idno><idno type="wicri:Area/Ncbi/Curation">009669</idno><idno type="wicri:Area/Ncbi/Checkpoint">009669</idno><idno type="wicri:doubleKey">0007-1226:1988:Piller N:a:double:blind</idno><idno type="wicri:Area/Main/Merge">00F004</idno><idno type="wicri:Area/Main/Curation">00E480</idno><idno type="wicri:Area/Main/Exploration">00E480</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health Sciences and Education, Sturt College Advanced Education, Bedford Park</wicri:regionArea><wicri:noRegion>Bedford Park</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, R Gwyn" sort="Morgan, R Gwyn" uniqKey="Morgan R" first="R. Gwyn" last="Morgan">R. Gwyn Morgan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Surgery, The Flinder's Medical Centre, Bedford Park</wicri:regionArea><wicri:noRegion>Bedford Park</wicri:noRegion></affiliation></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>The Henry Thomas Laboratory (Microcirculation Research), University of Adelaide, Box 498 GPO, Adelaide, SA 5001</wicri:regionArea><wicri:noRegion>SA 5001</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Plastic Surgery</title><title level="j" type="abbrev">YBJPS</title><idno type="ISSN">0007-1226</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">41</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="20">20</biblScope><biblScope unit="page" to="27">27</biblScope></imprint><idno type="ISSN">0007-1226</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1226</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Hydroxyethylrutoside (administration & dosage)</term><term>Hydroxyethylrutoside (analogs & derivatives)</term><term>Hydroxyethylrutoside (therapeutic use)</term><term>Leg</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Mastectomy</term><term>Middle Aged</term><term>Postoperative Complications (drug therapy)</term><term>Random Allocation</term><term>Rutin (analogs & derivatives)</term><term>Skin Temperature (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Attribution aléatoire</term><term>Bras</term><term>Complications postopératoires (traitement médicamenteux)</term><term>Essais cliniques comme sujet</term><term>Femelle</term><term>Humains</term><term>Jambe</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Mastectomie</term><term>Mâle</term><term>Méthode en double aveugle</term><term>O-(bêta-Hydroxyéthyl)rutosides (administration et posologie)</term><term>O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés)</term><term>O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique)</term><term>Rutoside (analogues et dérivés)</term><term>Température cutanée ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Hydroxyethylrutoside</term><term>Rutin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term><term>Rutoside</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Skin Temperature</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Arm</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Leg</term><term>Male</term><term>Mastectomy</term><term>Middle Aged</term><term>Random Allocation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Attribution aléatoire</term><term>Bras</term><term>Essais cliniques comme sujet</term><term>Femelle</term><term>Humains</term><term>Jambe</term><term>Mastectomie</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Température cutanée</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A randomised, double-blind, cross-over trial was performed on 26 patients with post-mastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took O-(β-hydroxyethyl)-rutosides (oxerutin; “Paroven®”, “Venoruton®”, Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p<0.05 to 0.01) and their circumferences (p<0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p<0.01 to 0.001). There was a lowering of the elevated skin temperatures (p<0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p<0.05 to 0.01), and an increased mobility of their limbs (p<0.0001). Most patients (70%) preferred the active drug (p<0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for the placebo (p<0.0001).</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name></noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name><name sortKey="Morgan, R Gwyn" sort="Morgan, R Gwyn" uniqKey="Morgan R" first="R. Gwyn" last="Morgan">R. Gwyn Morgan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00E480 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00E480 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F1AB2C3158F33CBC34B96C103F24B762D9D9564C
|texte= A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs
}}
| This area was generated with Dilib version V0.6.31. |  |